Which one of these is not like the others?

Below is an unedited email I received from my university Office of Sponsored Programs. Take a look at items 1-4 (see italicized text below).

AGENCY: Department of Health and Human Services (DHHS)/National Institutes of Health (NIH)

PROGRAM: Roadmap Transformative R01 Program (R01)

OBJECTIVES: This program, part of the NIH Roadmap Initiative, provides funding for exceptionally innovative, high risk, original and/or unconventional research with the potential to create new or challenge existing scientific paradigms.

Projects in any area of NIH interest are encouraged. Areas of highlighted need that have been identified through an NIH strategic planning process include: 1) Understanding and Facilitating Human Behavior; 2) Change Complex 3-Dimensional Tissue Models; 3) Functional Variation in Mitochondria in Disease Transitions from Acute to Chronic Pain; 4) Formulation of Novel Protein Capture Reagents; and 5) Providing an Evidence Base for Pharmacogenomics

Proposals must clearly articulate (a) the fundamental issue to be addressed and its overarching importance to the biomedical/behavioral research enterprise, (b) how the studies will either establish new or disrupt existing paradigms, and (c) how the proposed rationale and/or approaches significantly differ from state of the art in the field.

DEADLINES:
Letters of Intent (optional): December 29, 2008
Proposal submission: January 29, 2009
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See why the Annals of Improbable Research say that "Soft is Hard"?